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RESEARCH ARTICLES

1. HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association (2023), Scientific Reports, 13:14691.

Saman Majeed#, Lan Dang#, Md Majharul  Islam, Olamide Ishola, Peter P. Borbat, Steven J. Ludtke*, Elka R. Georgieva*

Texas Tech Publication

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2. Insights into the oligomeric structure of the HIV-1 Vpu protein (2023), J Struct Biol, 215, 107943.

Saman Majeed, Oluwatosin Adetuyi, Peter P. Borbat, Md Majharul Islam, Olamide Ishola, Bo Zhao, Elka R. Georgieva**

** Corresponding author

Texas Tech Publication

 

3. High-yield production in E. coli and characterization of full-length functional p13II protein from human T-cell leukemia virus type 1 (2020), Prot Expr Purif,  173:105659

Elka R. Georgieva**, Peter P. Borbat, Christina Fanouraki, Jack H. Freed

** Corresponding author

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4. A Facile Approach for the In Vitro Assembly of Multimeric Membrane Transport Proteins (2018) Elife, 7, pii: e36478.

Erika Riederer, Paul J. Focke, Elka R. Georgieva, Nurunisa Akyuz, Kimberly Matulef, Peter P. Borbat Jack H. Freed, Scott Blanchard, Olga Boudker and Francis I. Valiyaveetil

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5. Structural basis for membrane anchoring and fusion regulation of the Herpes Simplex Virus fusogen gB (2018) Nat Struct Mol Biol, 25, 416-424.

Rebecca S. Cooper, Elka R. Georgieva, Peter P. Borbat, Jack H. Freed, Ekaterina E. Heldwein. 

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6. Signature of an aggregation-prone conformation of tau (2017) Sci Rep, 7:44739.

Neil A. Eschmann, Elka R. Georgieva, Pritam Ganguly, Peter P. Borbat, Maxime Rappaport, Yasar Akdogan, Jack H. Freed, Joan-Emma Shea, Song-I Han.

 

7. A New Wavelet Denoising Method for Experimental Time-Domain Signals: Pulsed Dipolar Electron Spin Resonance (2017) J Phys Chem A, 121, 2452-2465.

Madhur Srivastava, Elka R. Georgieva, Jack H. Freed.

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8. Conformational response of influenza A M2 transmembrane domain to amantadine drug binding at low pH (pH 5.5) (2016) Frontiers in Physiology, 7:317.

Elka R. Georgieva*, Peter P. Borbat, Kirill Grushin, Svetla Stoilova-McPhie, Nichita J. Kulkarni, Zhichun Liang, Jack H. Freed*.

* Co-corresponding author  

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9. Pulsed dipolar spectroscopy reveals that tyrosyl radicals are generated in both monomers of the cyclooxygenase-2 dimer (2015) Biochemistry, 54, 7309-12.

Benjamin Orlando&, Peter P. Borbat&, Elka R. Georgieva&, Jack H. Freed, Michael G. Malkowski.

& Equal contribution

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10. Mechanism of influenza A M2 transmembrane domain assembly in lipid membranes (2015) Sci Rep, 5, 11757.

Elka R. Georgieva*, Peter P. Borbat, Haley D. Norman and Jack H. Freed*.

* Co-corresponding author 

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11. Transport domain unlocking sets the uptake rate of an aspartate transporter (2015) Nature, 518, 68-73.

Nurunisa Akyuz, Elka R. Georgieva, Zhou Zhou, Sebastian Stolzenberg, Michel A. Cuendet, George Khelashvili, Roger B. Altman, Daniel S. Terry, Jack H. Freed, Harel Weinstein, Olga Boudker and Scott C. Blanchard.

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12. Tau binds to membrane surfaces via short amphipathic helices located in its microtubule-binding repeats (2014) Biophys J, 107, 1441-52.

Elka R. Georgieva, Shifeng Xiao, Peter P. Borbat, Jack H. Freed and David Eliezer.

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13. Conformational ensemble of the sodium coupled aspartate transporter (2013) Nat Struct Mol Biol, 20, 215–22.

Elka R. Georgieva, Peter P. Borbat, Christopher Ginter, Jack H. Freed, Olga Boudker.

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14. Improved sensitivity for long-distance measurements in biomolecules: Five-pulse double electron−electron resonance (2013) J Phys Chem Lett, 4, 170-175.

Peter P. Borbat, Elka R. Georgieva, Jack H. Freed.

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15. Effect of freezing conditions on distances and their distributions derived from double electron electron resonance (DEER):  A study of doubly-spin-labeled T4 lysozyme (2012) J Magn Res, 216, 69-77.

Elka R. Georgieva, Aritro S. Roy, Vladimir M. Grigoryants, Petr P. Borbat, Keith A. Earle, Charles P. Scholes, Jack H. Freed.

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16. The lipid-binding domain of wild type and mutant alpha-Synuclein: Compactness and interconversion between the broken and extended helix forms (2010) J Biol Chem, 285, 28261-74.

Elka R. Georgieva, Trudy F. Ramlall, Peter P. Borbat, Jack H. Freed, David Eliezer.

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17. Membrane-bound alpha-Synuclein forms an extended helix: Long-distance pulsed   ESR measurements using vesicles, bicelles and rod-like micelles (2008) J Am Chem Soc, 130, 12856-7.

Elka R. Georgieva, Trudy F. Ramlall, Peter P. Borbat, Jack H. Freed, David Eliezer.

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18. Secondary structure conversions of Mycobacterium tuberculosis ribonucleotide reductase protein R2 under varying pH and temperature conditions (2008) Biophys Chem, 137, 43-48.

Elka R. Georgieva**, Ana Julia Narvaez, Niklas Hedin and Astrid Gräslund.

** Corresponding author

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19. High–field/high-frequency EPR study on stable free radicals formed in sucrose by gamma-irradiation (2006) Free Radical Res, 40, 553-563.

Elka R. Georgieva**, Luca Pardi, Gunnar Jeschke, Dante Gatteschi, Lorenzo Sorace, Nicola D. Yordanov.

** Corresponding author

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20. EPR and UV spectral study of gamma-irradiated white and burned sugar, fructose and glucose (2004) Spectrochim Acta Part A: Mol Biomol Spectroscopy, 60, 1307-1314.

Nicola D. Yordanov, Elka Georgieva.

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21. EPR and UV spectroscopic study of table sugar as a high-dose dosimeter (2002) Radiat Phys Chem, 65 269-276.

N. D. Yordanov, V. Gancheva, E. Georgieva.

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REVIEW ARTICLES

1. Engineered Chimera Protein Constructs to Facilitate the Production of Heterologous Transmembrane Proteins in E. coli (2024) Int J Mol Sci, 25, 2354.

Adeyemi Ogunbowale and Elka R. Georgieva **

** Corresponding author

Texas Tech Publication

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2. Lipid Membrane Mimetics in Functional and Structural Studies of Integral Membrane Proteins (2021) Membranes, 11(9), 685. (Invited)

Saman Majeed, Akram Bani Ahmad, Ujala Sehar, Elka R. Georgieva**

** Corresponding author

Texas Tech Publication

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3. Protein Conformational Dynamics upon Association with the Surfaces of Lipid Membranes and Engineered Nanoparticles: Insights from Electron Paramagnetic Resonance Spectroscopy (2020) Molecules, 25(22), 5393. (Invited)

Elka R. Georgieva**

** Corresponding author

Texas Tech Publication

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4. Non-structural proteins from human T-cell leukemia virus type 1 in cellular membranes—Mechanisms for viral survivability and proliferation (2018), Int J Mol Sci, 19, pii: E3508.

Elka R. Georgieva**.

** Corresponding author

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5. Nanoscale lipid membrane mimetics in spin-labeling and electron paramagnetic resonance spectroscopy studies of protein structure and function (2017) Nanotechnology Reviews, special issue on "Lipid nanotechnologies for macromolecular structure determination", 6, 75–92. (Invited)

Elka R. Georgieva**

** Corresponding author

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6. Some similarities and differences in the behavior of gamma-irradiated alanine and sugar in the solid state and in water solution (2002) Advanced EPR Applied to Biosciences, Editor: Asako Kawamori, Printed at Kwansei Gakun University, 128-134.

N. D. Yordanov, V. Gancheva, E. Georgieva.

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PREPRINTS

1. Engineered chimera proteins to facilitate the production of heterologous transmembrane proteins in E. coli by Adeyemi Ogunbowale, Elka R. Georgieva** (review article); doi:10.20944/preprints202401.1093.v1.

** Corresponding author

Texas Tech Publication

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2.  A comparative study of influenza A M2 protein conformations in DOPC/DOPS liposomes and in native E. coli membranes, bioRxiv, doi: https://doi.org/10.1101/2024.01.08.57468, (2024) by Griffin Sanders, Peter P. Borbat, Elka R. Georgieva** (research article)

** Corresponding author

Texas Tech Publication

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3. Protein engineering, production, reconstitution in lipid nanoparticles, and initial characterization of the Mycobacterium tuberculosis EfpA drug exporter (research article) bioRxiv, 

doi: https://doi.org/10.1101/2023.06.26.546575 (2023)

Olamide Ishola, Adeyemi Ogunbowale, Md Majharul Islam, Elaheh Hadadianpour, Saman Majeed, Oluwatosin Adetuyi, Elka R. Georgieva** 

** Corresponding author

Texas Tech Publication

 

4. HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association (research article) bioRxiv,  doi: https://doi.org/10.1101/2023.05.08.539839 (2023)

Saman Majeed#, Lan Dang#, Md Majharul  Islam, Olamide Ishola, Peter P. Borbat, Steven J. Ludtke*, Elka R. Georgieva* 

*Co-Corresponding author

Texas Tech Publication

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5. Oligomeric polymorphism of HIV-1 Vpu protein oligomer formation in solution and in lipid environment (research article) bioRxiv,  doi: https://doi.org/10.1101/2022.08.26.505453 (2022)

Saman Majeed, Oluwatosin Adetyui, Md Majharul Islam, Bo Zhao, Elka R. Georgieva**

** Corresponding author

Texas Tech Publication

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SELECTED CONFERENCE ABSTRACTS

1.Conformations of the HIV-1 Vpu protein in solution and lipids membranes: Insights from a multi-technique approach (2023) Prot Sci, Abstract issue. Saman Majeed, Lan Dang, Peter Borbat, Md Majharul Islam, Olamide Ishola, Steven J. Ludtke, Elka R. Georgieva**

Texas Tech Publication

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2. Insights into the structure-function relationship of the HIV-1 Vpu protein (2023) Biophys J, Abstract issue

Elka R. Georgieva**, Saman Mejeed, Oluwatosin Adetyui, Md Majharul Isalm​

Texas Tech Publication

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3. Cryo-EM snapshots and protein spin labeling in structural studies of HIV-1 Vpu (2023) Biophys J, Abstract issue

Md Majharul Islam, Oluwatosin Adetuyi, Saman Majeed, Olamide Ishola, Isaac Forester, Steven J. Ludtke, Elka R. Georgieva**

Texas Tech Publication

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4. Design of fusion constructs to facilitate the production and study of viral membrane proteins and their complexes (2022) Protein Sci, Abstract issue

Oluwatosin Adetyui, Saman Majeed, Md Majharul Islam, Elka R. Georgieva**

Texas Tech Publication

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5. Production of recombinant Mtb membrane efflux pump for structural and functional studies to reveal mechanisms of drug resistance (2022) FASEB J, Abstract issue

Elka R. Georgieva**, Akram Bani Ahmad, Oluwatosin Adetuyi, Saman Majeed

Texas Tech Publication

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6. Protein engineering and biochemical/biophysical approaches for structural studies of small membrane proteins and their complexes: Application to viroporins (2022), FASEB J, Abstract issue

Saman Majeed, Akram Bani Ahmad, Oluwatosin Adetuyi, Eric G. Evans, Stefan Stoll, Elka R. Georgieva**

Texas Tech Publication

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